Characterization of Cytochalasins and Steroids From the Ascomycete Daldinia concentricaand Their Cytotoxicity

Autor: Trung, Hoang Van, Kuo, Ping-Chung, Tuan, Nguyen Ngoc, Ngan, Nguyen Thi, Trung, Nguyen Quang, Thanh, Nguyen Tan, Hai, Ha Viet, Phuong, Doan Lan, Giang, Bach Long, Li, Yue-Chiun, Wu, Tian-Shung, Thang, Tran Dinh
Zdroj: Natural Product Communications; May 2019, Vol. 14 Issue: 5
Abstrakt: One new cytochalasin daldinin (1), 2 known cytochalasins 2and 3, along with 2 steroids 4and 5, were characterized from the methanol extracts of the fruiting bodies of Daldinia concentrica. The structure of new compound 1was elucidated using a combination of 1- and 2-dimensional nuclear magnetic resonance spectroscopic and high-resolution electrospray ionization mass spectrometric analyses. In addition, the isolated compounds were examined for their cytotoxicity against several tumor cell lines and the tested compounds demonstrated moderate-to-weak cytotoxicity.
Databáze: Supplemental Index