| Autor: |
Vanage, Geeta Ramesh, Salian, Smita, Tiwari, Dinesh, Kamble, Jyoti, Padwal, Varsha, Patil, Prakash S., Chilgunde, Swapnil |
| Zdroj: |
Biology of Reproduction; May 2008, Vol. 78 Issue: 1, Number 1 Supplement 1 p227-227, 1p |
| Abstrakt: |
Bisphenol A (BPA) is an estrogenic chemical which is widely used in consumer products. BPA is polymerized to produce polycarbonate plastics and resins. It is also used as an additive in other types of plastic, such as polyvinyl chloride (PVC) used in medical tubing, toys, and water pipes, and polyethylene terephathate (PET), used in soda and mineral water bottles. It is also one of the components of dental sealants. Until recently, BPA had been considered to be very week environmental estrogen with no genotoxic or carcinogenic potential. However recent studies have revealed a variety of pathways through which BPA can stimulate cellular response at very low doses. The present study describes the reproductive and genotoxic effects of BPA at doses very close to human exposure levels. Exposure of neonatal male rats to BPA over a period of five days resulted in an impairment of their reproductive functions during adulthood. In vivo studies carried out in rats, revealed cytogenetic damage in bone marrow cells. A dose dependent increase in micronucleus frequency was observed in polychromatic erythrocytes. Metaphase analysis of bone marrow cells demonstrated chromosomal aberrations in the form of chromosomal breaks, fragments, gaps, chromatid breaks, ring chromosomes and aneuploidy. Comet assay results revealed a dose dependent increase in the DNA damage in bone marrow as well as lymphocyte cell of BPA treated animals, indicating genotoxic activity of BPA at environmentally relevant doses. These in-vivo results demonstrate that BPA exhibits reproductive and genotoxic activity at environmentally relevant doses. |
| Databáze: |
Supplemental Index |
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