| Autor: |
Li, Jing, Zhang, Jian V., Cao, Yu-Jing, Zhou, Jia-Xi, Liu, Wei-Min, Fan, Xiu-Jun, Duan, En-Kui |
| Zdroj: |
Biology of Reproduction; March 2005, Vol. 72 Issue: 3 p700-706, 7p |
| Abstrakt: |
Beta-catenin, the mammalian homolog of Drosophilaarmadillo protein, was first identified as a cadherin-associated protein at cell-cell junctions. Another function of beta-catenin is the transduction of cytosolic signals to the nucleus in a variety of cellular contexts, which usually are elicited by the active form of beta-catenin. The aim of the present study was to examine the potential role of active beta-catenin in the mouse embryo and uterus during embryo implantation. Active beta-catenin was detected differentially in mouse embryos and uteri during the peri-implantation period. Aberrant activation of beta-catenin by LiCl, a well-known glycogen synthase kinase-3 inhibitor, significantly inhibited blastocyst hatching and subsequent adhesion and outgrowth on fibronectin. Results obtained from pseudopregnant and implantation-delayed mice imply an important role for implanting blastocysts in the temporal and spatial changes of active beta-catenin in the uterus during the window of implantation. Collectively, these results suggest that the beta-catenin signaling pathway is inhibited in both blastocyst and uterus during the window of implantation, which may represent a new mechanism to synchronize the development of preimplantation embryos and differentiation of the uterus during this process. |
| Databáze: |
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