| Autor: |
Longcope, C., Bourget, C., Meciak, P. A., Okulicz, W. C., Mc Cracken, J. A., Hoberg, L. M., Padykula, H. A. |
| Zdroj: |
Biology of Reproduction; October 1988, Vol. 39 Issue: 3 p561-565, 5p |
| Abstrakt: |
The metabolic clearance rates (MCR) and interconversions ([ρ]BB) values for estrone (E1) and estradiol (E2) in female rhesus (Macaca mulatta) monkeys on Days 9, 14, and 23 of the menstrual cycle were measured using constant infusions of [3H] estradiol and [14C] estrone. The menstrual cycles in these monkeys were reproduced by using Silastic capsules of E2and progesterone after bilateral ovariectomy. The serum levels of E2and progesterone were measured by radioimmunoassay and were similar to those for the intact menstrual cycle. The MCR of E2on Day 14 (52.8 ± 6.8 l/day/kg) was significantly greater (p < 0.05) than that measured on Day 9 (31.1 ± 3.6 l/day/kg) or Day 23 (35.4 ± 2.1 l/day/kg). The MCR of E1was also different (p < 0.05) on Day 14 (77.6 ± 14.9 l/day/kg) compared to the values on Days 9 and 23 (50.2 ± 4.9 and 48.2 ± 3.9 l/day/kg, respectively. There was no change in percentage of free E2, percentage of albumin-bound E2, or sex hormone-binding globulin levels on those 3 days of the cycle. The interconversions between E2and E1were not influenced by the day of the cycle. We conclude that the high levels of E2occurring at the time of the E2peak result in increases in the MCRs of both E2and E1that are not associated with changes in the pattern of protein-binding or in the activity of the 17β-hydroxy steroid dehydrogenase. |
| Databáze: |
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