| Autor: |
Farrar, John A., Handberg, Gwynneth M., Hartley, Margaret L., Pennefather, Jocelyn N. |
| Zdroj: |
Biology of Reproduction; April 1980, Vol. 22 Issue: 3 p473-479, 7p |
| Abstrakt: |
The levels of norepinephrine in the longitudinal layer of the myometrium, costo-uterine muscle and ovary of the guinea pig have been determined throughout the estrous cycle. Neither the concentration nor the total amount of amine in the ovary or costo-uterine muscle was found to fluctuate systematically during the 15 day cycle of the guinea pigs used. The concentration of norepinephrine was lower in the longitudinal layer of the myometrium when taken from animals in diestrus as compared to those in metestrus. Dopamine was present in ∼10% of the concentration of norepinephrine in the ovary and costo-uterine muscle and in slightly higher proportions in the myometrium.The absence of a change in the levels of norepinephrinc in the ovary and the costo-uterine muscle during the estrous cycle is consistent with earlier observations that only in tissues such as the uterus which receive innervation via short postganglionic neurones are the levels of norepinephrine steroid-dependent. In contrast, 28 days following hemiovariectomy, the levels of norepinephrine in the remaining ovary declined abruptly in association with the development of compensatory hypertrophy. These results are discussed in the context of suggestions that ovarian noradrenergic nerves participate in the development of compensatory hypertrophy. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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