| Autor: |
Patwardhan, Vasant V., Lanthier, André |
| Zdroj: |
Biology of Reproduction; March 1979, Vol. 20 Issue: 2 p221-225, 5p |
| Abstrakt: |
Sexually mature female rabbits were sacrified at 30 min, 1, 4, 5, 8 and 9 h after LH (50 µg) administration. From each animal, 8–10 follicles were isolated from both the ovaries, pooled and the total and free cholesterol contents were determined by the Schoenheimer-Sperry method. The total cholesterol content of the follicles was found to be significantly depleted with 30 min after LH administration as compared to saline-treated controls. The magnitude of this depletion was the same at all the time periods. The drop in cholesterol content was exclusively due to a drop in cholesterol esters and free cholesterol levels remained essentially unchanged. Pretreatment of the animals with indomethacin at a dose known to inhibit follicular prostaglandin biosynthesis prevented the LH-induced cholesterol depletion. These results are discussed in relation to the patterns of changes in steroid and prostaglandin concentrations that are known to occur in the LH-stimulated rabbit follicles. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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