| Autor: |
Jolly, Amber Leah, Rau, Sameeha, Chadha, Anmol K., Abdulraheem, Ekhlas Ahmed, Dean, Deborah |
| Zdroj: |
mBio; March 2019, Vol. 10 Issue: 2 |
| Abstrakt: |
Chlamydia trachomatisis a human pathogen and the leading cause of preventable blindness and sexually transmitted diseases in the world. Certain C. trachomatisstrains cause ocular disease, while others cause upper genital tract pathology. However, little is known about the cellular or immunologic basis for these differences. Here, we compared the abilities of the strain types to infect, replicate, and initiate an immune response in primary human ocular and urogenital epithelial cells, as well as in fibroblasts from the underlying stroma. While there were no significant differences in infection rates or intracellular growth for any strain in any cell type, proinflammatory responses were driven not by the epithelial cells but by fibroblasts and were distinct between ocular and urogenital strains. Our findings suggest that primary fibroblasts are a novel and more appropriate model for studies of immune responses that will expand our understanding of the differential pathological disease outcomes caused by various C. trachomatisstrain types. |
| Databáze: |
Supplemental Index |
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