| Autor: |
Hernández‐Ruiz, Marcela, Othy, Shivashankar, Herrera, Carolina, Nguyen, Hong‐Tam, Arrevillaga‐Boni, Gerardo, Catalan‐Dibene, Jovani, Cahalan, Michael D., Zlotnik, Albert |
| Zdroj: |
Journal of Leukocyte Biology; May 2019, Vol. 105 Issue: 5 p1027-1039, 13p |
| Abstrakt: |
CXCL17 is a homeostatic chemokine in the mucosa known to chemoattract dendritic cells and macrophages but can also be expressed elsewhere under inflammatory conditions. Cxcl17−/−mice have lower numbers of macrophages or dendritic cells in mucosal tissues. CXCL17 is also able to chemoattract suppressor myeloid cells that can recruit regulatory T cells. To explore a possible role of Cxcl17 in T cells, we studied T cell populations from Cxcl17−/−or wild‐type (WT) littermate mice. Cxcl17−/−mice have higher numbers of CD4+and CD8+T cells in spleen and lymph nodes (LNs). Upon activation, they produce higher levels of several proinflammatory cytokines and chemokines. Furthermore, a Cxcl17−/−mouse developed exacerbated disease in a T cell‐dependent model of experimental autoimmune encephalomyelitis (EAE). By 18 days after immunization with myelin oligodendrocyte peptide, only 44% of Cxcl17−/−mice were still alive vs. 90% for WT mice. During EAE, Cxcl17−/−mice exhibited higher numbers of lymphoid and myeloid cells in spleen and LNs, whereas they had less myeloid cell infiltration in the CNS. Cxcl17−/−mice also had higher levels of some inflammatory cytokines in serum, suggesting that they may be involved in the poor survival of these mice. Abnormal T cell function may reflect altered myeloid cell migration, or it could be due to altered T cell development in the thymus. We conclude that CXCL17 is a novel factor regulating T cell homeostasis and function. A Cxcl17−/−mouse is highly susceptible in an inflammatory model and exhibits alterations in the homeostasis and function of T cells. . |
| Databáze: |
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