| Autor: |
Hakim, S.Lokman, Roohi, S.W.A.Sharifah, Zurkurnai, Y., Rain, A.Noor, Mansor, S.M., Palmer, K., Navaratnam, V., Mak, J.W. |
| Zdroj: |
Transactions of the Royal Society of Tropical Medicine & Hygiene; May 1996, Vol. 90 Issue: 3 p294-297, 4p |
| Abstrakt: |
Uncomplicated falciparum malaria patients were randomly assigned to receive either 25 mg/kg chloroquine (CHL) over 3 d or a statimdose of 25 mg/kg sulfadoxine (SDX) plus 1.25 mg/kg pyrimethamine (PYR). Patients were followed up for 28 d and the parasite response graded according to World Health Organization criteria. Overall resistance to CHL was 63.3% and 47.4% to SDX/PYR. RI, RII and RIII rates were 9.1%, 42.4% and 12.1% for CHL and 10.5%, 21.1% and 15.8% for SDX/PYR, respectively. Degree and rates of resistance to CHL were significantly correlated with pre-treatment parasite density, but not those to SDX/PYR. Plasma CHL and SDX/PYR levels were within the reported ranges and were not significantly different in patients with sensitive and resistant responses. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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