| Autor: |
Barros, Keylla, Ribeiro Paulino, Marcília, Batista, Mara Ilka, Gueiros, Luiz, Souza, Paulo, Leão, Jair, Albuquerque Tavares Carvalho, Alessandra |
| Zdroj: |
Brazilian Journal of Microbiology; July 2019, Vol. 50 Issue: 3 p663-668, 6p |
| Abstrakt: |
Polymorphisms in the structural gene MBL-2 (mannose-binding lectin-2) may result in low MBL serum concentration, associated with greater susceptibility to infection. The study evaluated the effects of MBL-2 polymorphisms with the oral manifestations of the HSV in human immunodeficiency virus (HIV)-infected patients. An observational case-control study was carried out, with the sample comprising 64 HIV+ and 65 healthy individuals. The signs and symptoms of HSV oral infection were evaluated, and oral mucosa buccal smears were collected. Polymorphisms of the MBL-2 gene and HSV-1 DNA were amplified through real-time PCR. The data revealed that of 64 HIV+, 29.6% presented signs and symptoms of HSV oral infection. Of these, the HSV-1 DNA was detected through real-time PCR in 21% of cases, and in 13.3% of asymptomatic individuals. There was no statistically significant difference between the symptomatic (p= 1) and the asymptomatic (p= 0.52) individuals, HIV+ and HIV−. Different genotypes (AA, A0, or 00) did not contribute to the oral manifestation of HSV in the HIV+ patients (p= 0.81) or HIV− (p= 0.45). There was no statistically significant difference in either group (p= 0.52). No significant association was identified between the MBL-2 gene polymorphisms in the oral manifestation of HSV infection. However, further studies are recommended with larger population groups before discarding this interrelationship. |
| Databáze: |
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