| Autor: |
Donahoe, Patricia K., Ito, Yasuo, Marfatia, Sudir, Hardy Hendren, W. |
| Zdroj: |
Biology of Reproduction; October 1976, Vol. 15 Issue: 3 p329-334, 6p |
| Abstrakt: |
The secretory pattern of Mullerian Inhibiting Substance in the rat was documented by a graded organ culture assay on each day of the perinatal period and at more widely spaced intervals in the adult period. The influence of placenta and pituitary on Mullerian Inhibiting Substance production was studied. Fetal testicular fragments were displaced from target Mullerian ducts to determine if Mullerian Inhibiting Substance would act at a distance.Rat testes produced Mullerian Inhibiting Substance throughout the latter third of gestation. Its production continued during the first three weeks of extrauterine life, after which it disappeared, coincident with weaning. Hypophysectomy carried out after 20 days of age was ineffective in restoring Mullerian Inhibiting Substance activity to the adult rat testis. Placental fragments neither prolonged nor enhanced the Mullerian Inhibiting Substance activity of perinatal testes in organ culture. Mullerian Inhibiting Substance exerted its regressive effect on Mullerian ducts placed at a distance from a testicular source. |
| Databáze: |
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