| Autor: |
Wybran, Joseph, Chantler, Shireen, Hugh Fudenberg, H. |
| Zdroj: |
The Lancet; January 1973, Vol. 301 Issue: 7795 p126-129, 4p |
| Abstrakt: |
Lymphocytes from patients with chronic lymphatic leukæmia (C.L.L.) show a poor response to mitogens. Lymphocytes from these patients and from healthy patients were separated into two populations. One population, very rich in T cells, showed the same type of response for both the controls and patients. In contrast, the population poor in T cells derived from C.L.L. lymphocytes did not respond at all to mitogens. Recombination experiments indicate that the response can be restored by the addition of T cells. These findings demonstrate the presence of a normally reactive T-cell population in patients with C.L.L. It seems that the lack of responsiveness in C.L.L. is due to the dilution of normally responding cells. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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