ISOLATION OF NEW LYMPHOTROPIC RETROVIRUS FROM TWO SIBLINGS WITH HAEMOPHILIA B, ONE WITH AIDS

Autor: Vilmer, E., Rouzioux, C., Vezinet Brun, F., Fischer, A., Chermann, J.C., Barre-Sinoussi, F., Gazengel, C., Dauguet, C., Manigne, P., Griscelli, C., Montagnier, L.
Zdroj: The Lancet; April 1984, Vol. 323 Issue: 8380 p753-757, 5p
Abstrakt: A human T-lymphotropic retrovirus was isolated from cultured T lymphocytes from two siblings with haemophilia B. Patient 2 was healthy, but patient 1 had acquired immunodeficiency syndrome. The retrovirus differed from human T-cell leukaemia virus (HTLV) but it was similar to the lymphadenopathy-associated retrovirus (LAV) in its morphology and its major core protein (P25). Both patients had antibodies against LAV and patient 1's retrovirus, detected by an enzyme-linked immunosorbent assay or a radioimmunoprecipitation assay. Seroepidemiological data indicated the transmission of this retrovirus by plasma products.
Databáze: Supplemental Index