Polyaza[n]paracyclophanes as synthetic models of Zn containing enzymes. The role of a non coordinated nitrogen atom in the proximity of the metal

Autor: Altava, Belen, Burguete, M.Isabel, Luis, Santiago V., Miravet, Juan F., García-España, Enrique, Marcelino, Victor, Soriano, Conxa
Zdroj: Tetrahedron; March 1997, Vol. 53 Issue: 13 p4751-4762, 12p
Abstrakt: 2,6,9,13-Tetraaza[14]paracyclophane (3, B323) represents a simple model for Zn containing enzymes like HCAII which possess additional reactive groups in the proximity of the metal center. The Zn2+.3complex shows notable catalytic activity for the hydrolysis of p-nitrophenyl acetate. Structural modifications of 3which affect to the non coordinated nitrogen atom greatly modify the catalytic activity of the receptor.
Databáze: Supplemental Index
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