| Autor: |
Iwase, Katsumi, Hamada, Michiko, Kato, Kanefusa, Yamamoto, Haruo, Kobayashi, Naomi, Tsujimura, Toru, Himeno, Yumiko, Yamazaki, Naho, Inagaki, Asako, Jinbo, Shin, Nagasaka, Akio, Itoh, Mitsuyasu |
| Zdroj: |
The Endocrinologist; July 2005, Vol. 15 Issue: 4 p213-218, 6p |
| Abstrakt: |
Aldolase, a glycolytic enzyme, consists of 3 immunologically different subunits as the tetrameric form and may correlate with cell carcinogenesis. In the present study, we investigated the role of aldolase isozymes in the thyroid tissue of various thyroid disorders using immunohistochemical staining and highly sensitive enzyme immunoassay for quantitative analysis of the isozymes. Aldolase A had low tissue specificity but correlated with tumor proliferation. The relation to tumor proliferation, however, was found only in a few cases of the thyroid tumors. Aldolase B was barely detectable in these thyroid tissues. Aldolase C, however, had high activities suggesting the high thyroid tissue specificity, particularly for parafollicular cells. It was considered to be a useful marker of tumor cell differentiation. The analysis of these isozymes may be helpful for the diagnosis of medullary thyroid carcinoma and neuroendocrine tumors. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
