| Autor: |
Madeira, Juliana da Costa, Quinet, Yves Patric, Nonato, Dayanne Terra Tenório, Sousa, Paloma Leão, Chaves, Edna Maria Camelo, Júnior, José Eduardo Ribeiro Honório, Pereira, Maria Gonçalves, Assreuy, Ana Maria Sampaio |
| Zdroj: |
Natural Product Communications; September 2015, Vol. 10 Issue: 9 |
| Abstrakt: |
The South American giant ant, Dinoponera quadriceps(Hymenoptera, Formicidae, Ponerinae), produces proteinaceous venom that has antinociceptive, neuroprotective and antimicrobial effects, thereby supporting the popular use of these ants to treat asthma, rheumatism, earache and back pain. Anticoagulant activity is another biological property that has been shown for the venom of other hymenopteran species, like wasps. The aim of this study was to assess the anti-inflammatory, anticoagulant and antiplatelet properties of D. quadricepsvenom (DqV). DqV anti-inflammatory activity was assessed by intravenous administration in Swiss mice in the models of paw edema and peritonitis. In vitro, DqV was assessed in coagulation (activated partial thromboplastin time) and platelet aggregation tests. DqV inhibited (27–33%) the edema elicited by carrageenan and the leucocyte migration (43%) elicited by zymosan. DqV decreased by 57% and 42%, respectively, the content of malondialdehyde and nitrite in the peritoneal fluid. DqV prolonged (1.8x) the clotting time and decreased (27%) the platelet aggregation induced by adenosine diphosphate. The crude venom of D. quadricepspresents an anti-inflammatory effect in mice and in vitroanticoagulant and antiplatelet effects. |
| Databáze: |
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