| Autor: |
Pereira, Ticiana Praciano, Campos, Adriana Rolim, Leal, Luzia Kalyne A. M., Pierdoná, Taiana Magalhães, Toyama, Marcos H., Monteiro, Helena Serra Azul, Martins, Alice Maria Costa |
| Zdroj: |
Natural Product Communications; July 2010, Vol. 5 Issue: 7 |
| Abstrakt: |
The effect was investigated of the K+channel blocker, glibenclamide, on the ability of Crotalus durissus cumanensisvenom (CDCM) to promote peripheral antinociception. This was measured by formalin-induced nociception in male Swiss mice. CDCM (200 and 300 μg/kg) produced an antinociceptive effect during phase 2 in the formalin test. The effect of CDCM (200 μg/kg) was unaffected by the ATP-sensitive K+channel blocker glibenclamide (2 mg/kg). These results suggest that CDCM is effective against acute pain. However, the ATP-sensitive K+channels pathway is not contribuable to the antinociceptive mechanism of CDCM. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
