| Autor: |
Hoi, Tran Minh, Van Thai, Tran, Ha, Chu Thi Thu, Van Anh, Ha Thi, Minh, Phan Xuan Binh, Dat, Nguyen Tien |
| Zdroj: |
Natural Product Communications; May 2016, Vol. 11 Issue: 5 |
| Abstrakt: |
One new flavonol diglycoside, 4′,5-dihydroxy-3,3′,7-trimethoxyflavone 4′-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (1), and two known compounds (2–3) were isolated from the methanol extract of Anoectochilus annamensisAver. aerial parts. The effects were evaluated of all isolated compounds (1–3) on LPS-induced production of the inflammatory mediator nitric oxide (NO) by RAW264.7 cells. 4′,5-Dihydroxy-3,3′,7-trimethoxyflavone (2) was the most active while the addition of a rutinoside at C-4′ (compound 1) decreased the inhibitory activity. This is the first report on the chemical composition and biological activity of A annamensis. |
| Databáze: |
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