| Autor: |
Risaliti, Laura, Kehagia, Aspasia, Daoultzi, Eirini, Lazari, Diamanto, Bergonzi, Maria Camilla, Vergkizi-Nikolakaki, Souzana, Hadjipavlou-Litina, Dimitra, Bilia, Anna Rita |
| Zdroj: |
Journal of Drug Delivery Science and Technology; June 2019, Vol. 51 Issue: 1 p493-498, 6p |
| Abstrakt: |
Essential oils (EOs) have been widely used for their antimicrobial properties but their instability to light and high volatility can limit the clinical practice, therefore a useful strategy to improve their biopharmaceutical properties is represented by vesicular systems. This paper focuses on the development of Salvia trilobaand Rosmarinus officinalisEOs-loaded nanovesicles and their evaluation for antioxidant, antiinflammatory and antibacterial activities. GC-MS analyses revealed that Salvia trilobaand Rosmarinus officinalisEOs main constituents were eucalyptol (ca. 47 and 49% respectively) and camphor (ca. 11 and 12% respectively). Liposomes loaded with 100 μL/mL of EO, were optimised for their size, polydispersity index, ζ-potential, recovery, encapsulation efficiency (EE%), release properties and morphology. They both exhibited average sizes of about 200 nm with a ζ-potential between −20 mV and −35 mV, and PdI was about 0.25. EE% were ca. 57% for S. trilobaand ca. 65% for R. officinalis. Liposomes were stable over one month period if stored at 4 °C and possessed significant antioxidant, antiinflammatory and antibacterial activities. In particular they were active against Klebsiella pneumoniaeand more effective than the unformulated EOs. The findings suggest that these formulations can decrease the volatility of EOs, optimise their biological properties and defeat antimicrobial infections. |
| Databáze: |
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