| Autor: |
Twohig, Jason P., Cardus Figueras, Ana, Andrews, Robert, Wiede, Florian, Cossins, Benjamin C., Derrac Soria, Alicia, Lewis, Myles J., Townsend, Michael J., Millrine, David, Li, Jasmine, Hill, David G., Uceda Fernandez, Javier, Liu, Xiao, Szomolay, Barbara, Pepper, Christopher J., Taylor, Philip R., Pitzalis, Costantino, Tiganis, Tony, Williams, Nigel M., Jones, Gareth W., Jones, Simon A. |
| Zdroj: |
Nature Immunology; April 2019, Vol. 20 Issue: 4 p458-470, 13p |
| Abstrakt: |
The cytokine IL-6 controls the survival, proliferation and effector characteristics of lymphocytes through activation of the transcription factors STAT1 and STAT3. While STAT3 activity is an ever-present feature of IL-6 signaling in CD4+T cells, prior activation via the T cell antigen receptor limits IL-6’s control of STAT1 in effector and memory populations. Here we found that phosphorylation of STAT1 in response to IL-6 was regulated by the tyrosine phosphatases PTPN2 and PTPN22 expressed in response to the activation of naïve CD4+T cells. Transcriptomics and chromatin immunoprecipitation–sequencing (ChIP-seq) of IL-6 responses in naïve and effector memory CD4+T cells showed how the suppression of STAT1 activation shaped the functional identity and effector characteristics of memory CD4+T cells. Thus, tyrosine phosphatases induced by the activation of naïve T cells determine the way activated or memory CD4+T cells sense and interpret cytokine signals. |
| Databáze: |
Supplemental Index |
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