| Autor: |
Rectenwald, John E., Minter, Rebecca M., Rosenberg, Jason J., Gaines, Gregory C., Lee, Sean, Moldawer, Lyle L. |
| Zdroj: |
Shock; February 2002, Vol. 17 Issue: 2 p135-138, 4p |
| Abstrakt: |
Bioglass®is a bioactive, resorbable ceramic particle that was developed to assure binding to living tissues. Bioglass®is currently employed to fill osseus defects in oral surgery, and it possesses both unique anti-inflammatory and antimicrobial properties. In an effort to determine whether Bioglass®may be useful as an adjunct anti-inflammatory device in local inflammatory processes, we examined whether exposure of the peritoneal cavity to Bioglass®would induce a pro- or anti-inflammatory response, and then modulate a subsequent proinflammatory response to endotoxin. Three- to fifty-milligram doses of 5 m Bioglass®were administered intraperitoneally in C57BL/6 mice. Total leukocyte, myeloperoxidase, and cytokine levels in the peritoneal wash fluid were determined. In addition, the peritoneal cavity was pre-exposed to Bioglass®, and was then subjected to a subsequent endotoxin administration. All doses of Bioglass®were found to induce a significant peritoneal IL-6 response; however, Bioglass®did not induce a TNF-, IL-1, IL-10, or a white cell recruitment into the peritoneal lavage fluid. Pretreatment of the peritoneal cavity with Bioglass®produced a transient reduction in the proinflammatory response to endotoxin. We conclude that exposure to Bioglass®produces an IL-6 response without concurrent expression of TNF- or IL-1. Bioglass®appears to transiently suppress the inflammatory response to endotoxin, possibly through the early induction of IL-6. These findings suggest that Bioglass®may offer a unique approach in modifying the inflammatory response in local tissue compartments. |
| Databáze: |
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