| Autor: |
Elyas, Abdulmajid A., Patsalos, Philip N., Agbato, Olatoye A., Brett, Edward M., Lascelles, Peter T. |
| Zdroj: |
Therapeutic Drug Monitoring; September 1986, Vol. 8 Issue: 3 p288292-288292, 1p |
| Abstrakt: |
Various factors that may influence the simultaneous concentration of total and free carbamazepine CBZ and carbamazepine10,11epoxide CBZE in serum of 68 children mean age 11.8 ± 4.5 years with epilepsy were assessed. Separation of free and bound drug fractions was achieved by ultrafiltration, and CBZ and CBZE concentrations were determined using a sensitive high pressure liquid chromatographic technique. Thirty children were on CBZ monotherapy. Both total CBZ and CBZE serum concentrations correlated significantly with their respective free serum concentrations. CBZ was 81 ± 3 and CBZE 63 ± 9 bound. There was no correlation between the CBZ dose and either CBZ total or free serum concentrations. A statistically significant correlation was, however, observed between CBZ dose and simultaneous CBZE total and free concentrations. CBZ total and free concentrations correlated significantly with those of total CBZE. A significant negative correlation was observed between age and total r0.49, p < 0.01 and free r0.43, p < 0.025 CBZECBZ ratios. Concomitant drug therapy phenytoin, phenobarbitone, and sodium valproate significantly elevated CBZECBZ ratios. |
| Databáze: |
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