Pulmonary Toxicity Caused by Cytotoxic Drugs

Autor: Roig, Jorge, Domingo, Christian, Gea, Elvira
Zdroj: Clinical Pulmonary Medicine; January 2006, Vol. 13 Issue: 1 p53-62, 10p
Abstrakt: Chemotherapy is the cornerstone of treatment in many stages of cancer. Because there are many diagnostic options when a patient with cancer presents with nonspecific, respiratory, clinical manifestations, a multidisciplinary diagnostic approach is warranted. The top priority is to rule out life-threatening causes such as lung infection, which could be properly treated if a prompt, accurate diagnosis is given. Reaching a definitive diagnosis may require the use of one or more invasive techniques. This review highlights the risks and characteristics of chemotherapy-induced pulmonary toxicity caused by those agents that have been commonly used to treat cancer in the last decade. Clinicians should keep a high index of suspicion when a possible diagnosis of chemotherapy-induced lung toxicity is concerned, because early withdrawal of the offending drug is the most efficacious therapy.
Databáze: Supplemental Index