| Autor: |
Brazeal, Brad A., Traber, Daniel L. |
| Zdroj: |
Current Opinion in Anaesthesiology; February 1997, Vol. 10 Issue: 1 p65-67, 3p |
| Abstrakt: |
Recent discoveries in smoke inhalation injury have come from a few investigators only. Our laboratory began looking at an ovine model that isolates the right and left lung to determine whether there was a probable hematogenous spread of the pulmonary response to smoke inhalation and specifically to examine the effect of bronchial blood flow. Nitric oxide has been found to decrease pulmonary edema and L-selectin to decrease plasma conjugated dienes. Also, investigators have documented that the major change in vascular resistance occurs across the venous segment. Metabolically, the breakdown of bradykinin does not change so long as the integrity of the lung's alveolarcapillary interface is maintained. Finally, the alveolar macrophage has shown a marked impairment to fighting a bacterial infection after inhalation injury. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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