| Autor: |
RUBINSTEIN, ARYE, GOLDSTEIN, HARRIS, CALVELLI, THERESA, DEVASH, YAIR, RUBINSTEIN, RAN, SOEIRO, RUY, LYMAN, WILLIAM |
| Zdroj: |
Pediatric Research (Ovid); January 1993, Vol. 33 Issue: 1, Number 1 Supplement 1 pS76-S79, 4p |
| Abstrakt: |
The increase in the number of human immunodeficiency virus1 HIV1infected children is a direct consequence of the heterosexual spread of the disease to women and the growing number of HIVpositive i.v. drug users. It is not known how the majority of infants born to HIV1infected women escape HIV1 infection, and, for those infected, the timing of HIV1 transmission has yet to be determined. In addition, the role of maternal antibodies in the prevention of HIV1 transmission to the fetus is unclear. We have previously demonstrated a correlation between vertical transmission and the absence of highaffinityavidity antibodies to a peptide, KRIHIGPGRAFYT, which corresponds to a region of the primary neutralizing domain of the gp120 V3loop of HIVMNMNPND. The present study examines the correlation between the presence of these high affinity antibodies in women completing a pregnancy or undergoing an elective abortion and the detection of HIV1 infection in their aborted fetuses. In several instances, transmission occurred despite highaffinity antibodies to the MNPND. We have, therefore, evaluated the reactivity of sera to different MNPND variants. In one infant born to a mother with highaffinityavidity antibodies to KRIHIGPGRAFYT classic MNPND, the infected baby developed antibodies to an MNPND variant peptide against which his mother did not mount a humoral immune response during pregnancy. This finding indicates that fetal infection with MNPND escape mutants arising during pregnancy may occur during a period when the mother is serologically negative. Pediatr Res33 Suppl S76S79, 1993 |
| Databáze: |
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