| Autor: |
KORDA, ANDREW R., FLEMING, SUSAN F., SENIOR, CECILIA, DUCKCHONG, CORAL G., HENDERSONSMART, DAVID J., RAMSEY, GAVIN, SHUTT, DONALD A., RUSSELL, PETER, SHEARMAN, RODNEY P. |
| Zdroj: |
Pediatric Research (Ovid); October 1984, Vol. 18 Issue: 10 p932935-932935, 1p |
| Abstrakt: |
Saline or triiodothyronine T3501000 g was injected into the amniotic sac of 17 pregnant ewes under general anesthesia at 130 days gestation. Fortyeight h later, the lambs were delivered by hysterotomy. Cord plasma T3and cortisol and amniotic fluid T3were assayed, and the maturity of the fetal lung was assessed in terms of its pressurevolume response and its surfactant lamellar body phospholipid content. With the highest dose of T3, cord plasma T3and cortisol were raised, and lung maturity was enhanced compared with salinetreated controls the pressurevolume curve showed increased hysteresis on inflation and deflation, and the lung retained air on return to zero pressure. There was also an apparent, but not statistically significant, increase in the lamellar body phospholipid content of the lung. Irrespective of treatment, lungs which were more mature, in terms of their pressurevolume characteristics, tended to contain a higher proportion of lamellar body phospholipid relative to total phospholipid. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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