| Autor: |
FRIEDMAN, SHLOMO, ATWATER, JEAN, GILL, FRANCES M., SCHWARTZ, ELIAS |
| Zdroj: |
Pediatric Research (Ovid); December 1974, Vol. 8 Issue: 12 p955-959, 5p |
| Abstrakt: |
A total of 104 of 693 Negro infants (15.0) had moderate or small amounts of hemoglobin Barts visible on starch gel electrophoresis. Moderate amounts were found in 21 infants (3.0) and small amounts in 83 infants (12.0). In 17 Negro infants judged to have moderate amounts of Hb Barts, the quantitation showed 2.0–9.3 with a mean of 5.4 ± 2.1 (1 SD). A significant decrease in mean cell volume and mean cell hemoglobin was found in the Negro neonate with more than 2 Hb Barts studied at 4 days of age. In 10 Negro infants with more than 2.0 Hb Barts studied at 4 days of age, the α α/(β + γ) ratio was 0.97 ± 0.06 (1 SD) (range 0.88–1.06). In nine infants aged 5—24 months who had more than 2.0 Hb Barts in the newborn period, including six infants studied in the first group, the mean α/β ratio was 0.74 ± 0.06, (range 0.65–0.83). Each of the nine infants with more than 2.0 Hb Barts at birth had marked microcytosis and hypochromia at 5—24 months despite adequate iron therapy. Two newborn infants with moderate levels of Hb Barts at birth (8.2 and 6.8) and balanced total globin synthesis had no free radioactive α chain by gel filtration studies. Our studies indicate clearly that the presence of more than 2 Hb Barts in the newborn period denotes the presence of α-thalassemia trait. |
| Databáze: |
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