| Autor: |
DURIE, PETER R., LARGMAN, COREY, BRODRICK, JAMES W., JOHNSON, JANICE H., GASKIN, KEVIN J., FORSTNER, GORDON G., GEOKAS, MICHAEL C. |
| Zdroj: |
Pediatric Research (Ovid); October 1981, Vol. 15 Issue: 10 p1351-1355, 5p |
| Abstrakt: |
Plasma immunoreactive cationic trypsin(ogen) levels were determined in 32 control subjects and 43 patients with varying degrees of pancreatic insufficiency including 35 with cystic fibrosis (CF) and eight with Shwachman's syndrome. In six CF infants less than 2 years of age, plasma trypsin(ogen) levels were significantly elevated (97.3 ± 62.2 ng/ml) above the normal range for nine controls (7.0 ± 5.9 ng/ml; P< 0.025). Four of these infants had steatorrhea, three of whom had undetectable duodenal trypsin activity after stimulation with secretin-cholecystokinin. In two CF infants, molecular size fractionation by gel filtration of plasma followed by radioimmunoassay of the column fractions demonstrated that trypsinogen was the only immunoreactive species in the circulation. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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