| Autor: |
KIKAWA, YOSHIHARU, HOSOI, SUSUMU, INOUE, YASUHIRO, SAITO, MASAKAZU, NAKAI, AKIO, SHIGEMATSU, YOUSUKE, HIRAO, TAKAO, SUDO, MASAKATSU |
| Zdroj: |
Pediatric Research (Ovid); May 1991, Vol. 29 Issue: 5 p455-459, 5p |
| Abstrakt: |
Urinary levels of leukotriene (LT) E4, a stable end-product of LTC4and LTD4, were measured before and after exercise in 10 children with severe asthma and seven children with moderate asthma using HPLC and RIA to clarify the relationship of LT to the severity of asthma and to the degree of bronchospasm in exercise-induced asthma. The urinary LTE4level significantly increased after exercise in the severe asthma group, but not in the moderate asthma group (14.3 ± 14.5 to 24.3 ± 20.6 versus19.6 ± 12.3 to 17.6 ± 10.8 ng/mmol creatinine, p< 0.05). The urinary LTE4level increased in 10 patients (eight with severe asthma), and it decreased in seven patients (five with moderate asthma). A significant difference in the degree of bronchospasm after exercise (as shown by the maximal fall in the peak expiratory flow rate), was seen when patients with increased urinary LTE4excretion were compared with those with decreased excretion (60.4 ± 17.3 versus24.1 ± 14.3, p< 0.01). Our findings suggest that exercise-induced asthma, or at least a subtype of exercise-induced asthma, may partly develop through the release of LTC4. |
| Databáze: |
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