| Autor: |
KUIPERS, IRENE M., MAERTZDORF, WIEL J., JONG, DICK S. DE, HANSON, MARK A., BLANCO, CARLOS E. |
| Zdroj: |
Pediatric Research (Ovid); January 1997, Vol. 41 Issue: 1 p90-95, 6p |
| Abstrakt: |
In uterobreathing activity is present periodically, but it must become continuous at birth. We investigated the effect of hypercapnia and of hypercapnia combined with central cooling on fetal breathing in seven chronically instrumented fetal lambs of 131-134-d gestation, using an extracorporeal membrane oxygenation (ECMO) system to control fetal blood gases and fetal temperature. During fetal hypercapnia (from a partial pressure of arterial CO2(Paco2) 6.18 ± 0.11 kPa to Paco27.39± 0.15 kPa) frequency, amplitude, and incidence of fetal breathing movements during low voltage electrocortical activity (LV ECoG) increased significantly compared with isocapnic control on ECMO, but breathing remained absent during high voltage electrocortical activity (HV ECoG). During hypercapnia accompanied by central cooling (Paco27.90 ± 0.13 kPa, temperature decreased by 2.1°C) there were similar changes in fetal breathing movements during LV ECoG, but in four out of seven fetuses fetal breathing movements continued throughout HV ECoG. Hypercapnia accompanied by central cooling can thus override the inhibitory effects of HV ECoG on fetal breathing movements. This may be due to changes in sensitivity to CO2produced by an increase in afferent input to the CNS. |
| Databáze: |
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