| Autor: |
OGIHARA, TOHRU, OKAMOTO, RYOZO, KIM, HAN-SUK, NAGAI, AKIRA, MORINOBU, TAKAO, MOJI, HIDEKI, KAMEGAI, HIDEKI, HIRANO, KAZUYA, OGIHARA, HIROMI, TAMAI, HIROSHI, MINO, MAKOTO |
| Zdroj: |
Pediatric Research (Ovid); January 1996, Vol. 39 Issue: 1 p117-119, 3p |
| Abstrakt: |
We measured the plasma concentration of allantoin, an oxidation product of uric acid and an “in vivo” marker of free radical generation, within 24-48 h after birth in 10 premature infants who subsequently developed chronic lung disease (CLD) and 9 infants without CLD(non-CLD). The plasma allantoin level (mean ± SD, 25.9 ± 9.8μM for CLD versus11.0 ± 5.7 μM for non-CLD,p< 0.01) and the allantoin/urate ratio (5.8 ± 2.0% for CLD infants versus2.4 ± 0.9% for non-CLD infants,p< 0.01) were significantly higher in the CLD group than those in the non-CLD group. These observations suggest the possible involvement of oxygen radicals in triggering CLD. In addition, the plasma allantoin concentration and the allantoin/urate ratio may be useful early predictors of the development of CLD. |
| Databáze: |
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