| Autor: |
Özdemir, Vural, Kalow, Werner, Okey, Allan B., Lam, Maria S. M., Albers, Lawrence J., Reist, Christopher, Fourie, Jeanne, Posner, Paul, Collins, Evan J., Roy, Rochelle |
| Zdroj: |
Journal of Clinical Psychopharmacology; December 2001, Vol. 21 Issue: 6 p603-607, 5p |
| Abstrakt: |
Antipsychotic response to clozapine varies markedly among patients with schizophrenia. The disposition of clozapine is dependent, in part, on the cytochrome P-450 (CYP) 1A2 enzyme in vivo. In theory, a very high CYP1A2 activity may lead to subtherapeutic concentrations and treatment resistance to clozapine. This prospective case study evaluates the clinical significance of ultrarapid CYP1A2 activity and a recently discovered single nucleotide (C → A) polymorphism in intron 1 of the CYP1A2gene (CYP1A2*F) for treatment resistance to clozapine. In addition, we describe the effect of grapefruit juice or low-dose fluvoxamine (25–50 mg/d) coadministration on clozapine and active metabolite norclozapine steady-state plasma concentration and antipsychotic response. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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