The Use of Parenteral Clindamycin in the Treatment of Obstetric-Gynecologic Patients With Severe Infections

Autor: LEDGER, WILLIAM J., KRIEWALL, TIMOTHY J., SWEET, RICHARD L., FEKETY, F ROBERT
Zdroj: Obstetrics & Gynecology (Ovid); April 1974, Vol. 43 Issue: 4 p490-497, 8p
Abstrakt: Using a system of random selection in patients with severe obstetric—gynecologic infections. parenteral penicillia-kanamycin was given to 23 women and clindaniycin-kanamycin was given to 21. Therapeutic response to the two antibiotic regimens was similar; no significant differences were noted in either the posttreatment fever index or the numbers of women requiring other therapy. There was a failure of response to the penicillia-kanamycin regimen in those women with Bacteroides fragilis infection and to the clindamycin-kanamycin regimen in some of the women with an Enterococcus infection. The implications of these findings for the future selection of antibiotics for patients with severe obstetric-gynecologic infections are discussed.
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