| Autor: |
HERSHEY, DOUGLAS W., CRANDALL, BARBARA F., PERDUE, SONDRA |
| Zdroj: |
Obstetrics & Gynecology (Ovid); August 1986, Vol. 68 Issue: 2 p177-180, 4p |
| Abstrakt: |
Twenty-eight cases of Down syndrome with maternal scrum α-fetoprotein (AFP) measured at second trimester were added to 137 previously reported cases. Seventy-eight percent of affected pregnancies had levels at or below the median AFP value, compared with 50 of unaffected pregnancies. Maternal age at delivery and serum AFP levels by multiples of the median were used to construct a table to determine the risk of Down syndrome. This was compared with the risk for a 35-year-old woman (one in 365). Similar risks were estimated for a 21-year-old with AFP below 0.4 multiples of the median, a 23-year-old below 0.5, a 26-year-old below 0.6, and a 29-year-old below 0.7 multiples of the median. This study provides guidelines for counseling pregnant women who have low serum AFP levels. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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