| Autor: |
Castillo, Judit, Knol, Jaco C., Korver, Cindy M., Piersma, Sander R., Pham, Thang V., de Goeij-de Haas, Richard R., van Pelt, Ans M.M., Jimenez, Connie R., Jansen, Bastiaan J.H. |
| Zdroj: |
Molecular and Cellular Proteomics (MCP Online); March 2019, Vol. 18 Issue: 1, Number 1 Supplement 1 pS132-S144, 13p |
| Abstrakt: |
Global phosphoproteomics on human testicular tissue was performed by using highly efficient titanium dioxide (TiO2) method coupled to LC-MS/MS. Mass spectrometry data were used to predict the most prominent kinases, and phosphoregulation was revealed as highly active during spermatogenesis. Protein kinases are good targets for pharmacological intervention in male fertility and testicular cancer progression. In fact, CDK12 and PAK4 were found to be potentially involved in the formation of sperm structures and cancer cell response to apoptosis, respectively. |
| Databáze: |
Supplemental Index |
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