| Autor: |
LUBANI, M. M., DUDIN, K. I., SHARDA, D. C., NDHAR, MANA D. S., ARAJ, G. F., HAFEZ, H. A., ALSALEH, Q. A., HELIN, I., SALHI, M. M. |
| Zdroj: |
The Pediatric Infectious Disease Journal; February 1989, Vol. 8 Issue: 2 p75-78, 4p |
| Abstrakt: |
A 6year multicenter therapeutic study was performed on 1100 children with brucellosis in order to compare several antibiotic combinations and duration of treatment. The patients were randomized to receive oral therapy with oxytetracycline, doxycycline, rifampin and trimethoprimsulfamethoxazole TMPSMX either alone or in combination with each other or combined with streptomycin or gentamicin injections. The patients were also randomized into three groups based on the duration of oral therapy 500 patients were treated for 3 weeks 350 for 5 weeks and 250 for 8 weeks. When intramuscular aminoglycosides were used, streptomycin was given for 2 weeks and gentamicin for 5 days. In oral monotherapy oxytetracycline, doxycycline and rifampin showed comparable results with low relapse rates =9 and no statistically significant differences were found among 3, 5 or 8week durations of therapy. TMPSMX alone showed an unacceptably high relapse rate 30 with all durations of therapy. In combined oral therapy rifampin plus oxytetracycline, rifampin plus TMPSMX and oxytetracycline plus TMPSMX showed comparable results with low relapse rates ranging from 4 to 8 in patients receiving therapy for 3 or 5 weeks, no relapses occurred in patients treated for 8 weeks. When oral monotherapy was combined with either streptomycin or gentamicin, very few relapses were seen, irrespective of the duration of treatment. We conclude that appropriate therapy for brucellosis in children =8 years of age is the combination of TMPSMX for 3 weeks with gentamicin given during the first 5 days, whereas in children >8 years old a combination of doxycycline or oxytetracycline for 3 weeks and gentamicin for the initial 5 days is recommended. |
| Databáze: |
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