DONOR-SPECIFIC HYPOREACTIVITY AFTER LIVER TRANSPLANTATION

Autor: de Haan, Aalzen, Berg, Arie P. van den, Hepkema, Bouke G., van Dijk, Elinda, Haagsma, Elizabeth B., The, T. Hauw, Slooff, Maarten J.H., Lems, Simon P.M., Leij, Lou F.M.H. de, Prop, Jochum
Zdroj: Transplantation; August 1998, Vol. 66 Issue: 4 p516-522, 7p
Abstrakt: The development of immunological donor-specific hyporeactivity may account for the low incidence of chronic rejection after clinical liver transplantation. We investigated whether hyporeactivity commonly develops after liver transplantation by analyzing precursor frequencies of donor-reactive cytotoxic (CTLp) and helper (HTLp) T lymphocytes and mixed lymphocyte culture (MLC) reactivity in liver allograft recipients. We further studied whether CTLp hyporeactivity correlated with changes in donor-specific HTLp frequencies or suppressor cell activity.
Databáze: Supplemental Index