Autor: |
Maeda, Takashi, Murase, Noriko, Subbotin, Vladimiar, Sakamoto, Toshiki, Yamada, Takaharu, Terakura, Masanobu, Todo, Satoru |
Zdroj: |
Transplantation; October 1998, Vol. 66 Issue: 7 p844-851, 8p |
Abstrakt: |
Cyclic nucleotides mediate intracellular signal transduction of several vasodilators. In addition to its vascular relaxant effects, cAMP is known to protect endothelial cells and to suppress Kupffer cell activation. On the other hand, cGMP potently ameliorates adhesion of leukocytes and platelets. We tested the effects of two analogs of cyclic nucleotides (8bromo cyclic adenosine monophosphate [8br-cAMP] and 8bromo cyclic guanosine monophosphate [8br-cAMP]) in rat liver preservation. |
Databáze: |
Supplemental Index |
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