INTRAGRAFT OVEREXPRESSION OF INTERLEUKIN-4 IS NEITHER SUFFICIENT NOR ESSENTIAL FOR TOLERANCE INDUCTION TO CARDIAC ALLOGRAFTS IN A HIGH-RESPONDER STRAIN COMBINATION1

Autor:	Ritter, Thomas, Risch, Kirsten, Schroder, Grit, Kolls, Jay, Siegling, Angela, Graser, Elmara, Reinke, Petra, Brock, Josef, Lehmann, Manfred, Volk, Hans-Dieter
Zdroj:	Transplantation; November 1999, Vol. 68 Issue: 9 p1427-1431, 5p
Abstrakt:	Recently we have demonstrated that the nondepleting anti-CD4 monoclonal antibody (mAb) RIB5/2 induces long-term acceptance of kidney and heart allografts in all rat strain combinations tested. Cytokine gene expression studies by reverse transcriptase-polymerase chain reaction revealed a reversed intragraft interleukin (IL)-4/interferon-γ ratio. Whether IL-4 mediated immune deviation contributes to transplantation tolerance is not clear so far.
Databáze:	Supplemental Index
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