PANCREATIC ISLET XENOGRAFT TOLERANCE AFTER SHORT-TERM COSTIMULATION BLOCKADE IS ASSOCIATED WITH INCREASED CD4 T CELL APOPTOSIS BUT NOT IMMUNE DEVIATION1, 2

Autor: Lehnert, Anne M., Yi, Shounan, Burgess, Jane S., O’Connell, Philip J.
Zdroj: Transplantation; March 2000, Vol. 69 Issue: 6 p1176-1185, 10p
Abstrakt: Our purpose was to determine if short-term inhibition of the CD40/CD40L and CD28/B7 costimulatory pathways was capable of inducing specific unresponsiveness to pancreatic islet xenografts and to ascertain the mechanism of tolerance induction.
Databáze: Supplemental Index