A 12-DAY COURSE OF FK506 ALLOWS LONG-TERM ACCEPTANCE OF SEMI-IDENTICAL LIVER ALLOGRAFT IN INBRED MINIATURE SWINE1

Autor: Oike, Fumitaka, Talpe, Stephanie, Otsuka, Masayuki, Dehoux, Jean Paul, Lerut, Jan, Otte, Jean Bernard, Gianello, Pierre
Zdroj: Transplantation; June 2000, Vol. 69 Issue: 11 p2304-2314, 11p
Abstrakt: Spontaneous tolerance to liver allograft has been reported previously in outbred pig models, but the lack of genetic background did not allow to analyze the impact of the major histocompatibility complex (MHC) on tolerance induction. A model of semi-identical liver allograft was therefore developed in inbred miniature swine in order to mimic the clinical situation of living related liver transplant (parent into infant) and to study a protocol for inducing tolerance to liver allograft.
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