| Autor: |
Chowdhury, Nepal C., Saborio, David V., Garrovillo, Mel, Chandraker, Anil, Magee, Colm C., Waaga, Ana M., Sayegh, Mohamed H., Jin, Ming-Xing, Oluwole, Soji F. |
| Zdroj: |
Transplantation; October 1998, Vol. 66 Issue: 8 p1059-1066, 8p |
| Abstrakt: |
Because T cell receptor-MHC class I/self-peptide interactions regulate T-cell development, the presence of MHC allopeptides in the thymus may influence T-cell tolerance to alloantigens. This hypothesis is supported by our most recent finding that intrathymic (IT) inoculation of nonimmunogenic synthetic peptides derived from "WAG" RT1.A induces tolerance to cardiac allografts in the Wistar-Furth (WF)-to-ACI model. To evaluate whether in vivo immunogenicity of MHC peptides is relevant to tolerance induction and to examine the effect of peptide specificity, we compared the effects on graft survival of well-defined, strain-specific immunogenic WF MHC class I peptides (RT1.AU) with closely related but non-strain-specific class I peptides derived from WAG (RT1U). |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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