TNF-, IL-6, IFN-, AND IL-10 GENE EXPRESSION POLYMORPHISMS AND THE IL-4 RECEPTOR -CHAIN VARIANT Q576R EFFECTS ON RENAL ALLOGRAFT OUTCOME

Autor: Hahn, Amy B., Kasten-Jolly, Jane C., Constantino, Don M., Graffunder, Eileen, Singh, T. Paul, Shen, Gary K., Conti, David J.
Zdroj: Transplantation; August 2001, Vol. 72 Issue: 4 p660-665, 6p
Abstrakt: There has been much interest recently in the effects of various cytokine gene expression polymorphisms on graft outcome. However, the results of these investigations reveal the outcomes to be organ-specific and center-specific. We sought to confirm and add to some of the earlier findings by studying the impact of tumor necrosis factor- (TNF-), interleukin-10 (IL-10), interferon- (IFN-), and interleukin-6 (IL-6) polymorphisms and the interleukin-4 (IL-4) receptor -chain variant on posttransplant renal allograft outcome.
Databáze: Supplemental Index