| Autor: |
Lakey, Jonathan R. T., Helms, Lisa M. H., Kin, Tatsuya, Korbutt, Gregory S., Rajotte, Ray V., Shapiro, A. M. James, Warnock, Garth L. |
| Zdroj: |
Transplantation; August 2001, Vol. 72 Issue: 4 p565-570, 6p |
| Abstrakt: |
Islet isolation from the pancreatic tissue matrix remains highly variable. Recent evidence suggests that intrinsic human pancreatic proteases, including trypsin, may inhibit effective collagenase enzymatic activity during islet isolation, thereby impairing the isolation success. In this study we have hypothesized that serine protease inhibition applied during pancreatic digestion, could improve yield and/or functional viability of islets isolated from human pancreases. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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