Chemokine and chemokine receptor gene expression indicates acute rejection of human cardiac transplants1

Autor: Fahmy, Nader M., Yamani, Mohamad H., Starling, Randall C., Ratliff, Norman B., Young, James B., McCarthy, Patrick M., Feng, Jingyuan, Novick, Andrew C., Fairchild, Robert L.
Zdroj: Transplantation; January 2003, Vol. 75 Issue: 1 p72-78, 7p
Abstrakt: Factors directing T-cell infiltration into allografts during acute rejection remain poorly defined. Chemokines have been shown to mediate leukocyte recruitment into allografts in animal models of rejection. The goal of this study was to test the presence and levels of chemokine and receptor gene expression in serial endomyocardial biopsy specimens from heart transplant patients and to correlate the levels observed with histopathologic rejection grade.
Databáze: Supplemental Index