| Autor: |
Ben-Ari, Ziv, Hochhauser, Edith, Burstein, Idan, Papo, Orit, Kaganovsky, Ella, Krasnov, Tatyana, Vamichkim, Alexey, Vidne, Bernardo A. |
| Zdroj: |
Transplantation; June 2002, Vol. 73 Issue: 12 p1875-1880, 6p |
| Abstrakt: |
Warm ischemia/reperfusion injury during liver transplantation is the most important cause of primary nonfunction of liver allografts. Tumor-necrosis factor (TNF)- apparently mediates tissue damage by inducing apoptosis and/or necrosis in liver transplants. The aim of the study was to determine, using an isolated rat liver model, if pretreatment with anti-TNF- monoclonal antibodies can attenuate ischemia/reperfusion liver injury. Specifically, its effect on liver cell apoptosis through the modulation of caspase activity was examined in a blood-free environment. |
| Databáze: |
Supplemental Index |
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