| Autor: |
Smyrniotis, Vassilios E., Kostopanagiotou, Georgia, Theodoraki, Kassiani, Gamaletsos, Evangelos, Kondi-Pafiti, Agathi, Mystakidou, Kyriaki, Arkadopoulos, Nikolaos |
| Zdroj: |
Transplantation; May 2003, Vol. 75 Issue: 10 p1737-1740, 4p |
| Abstrakt: |
Segmental liver grafts with a calculated ideal liver weight (CILW) less than 40 may be associated with portal flow-related injuries and primary dysfunction. This study evaluated the effect of mesocaval shunts on the survival of grafts with a CILW less than 20. Sixteen pigs underwent orthotopic transplantation of segmental liver grafts with a CILW less than 20. In eight animals (study group), transplantation was combined with a mesocaval shunt, and eight animals served as controls without a mesocaval shunt. Liver function, systemic hemodynamics, portal vein pressure, intracranial pressure, and cerebral perfusion pressure were assessed postoperatively. The controls showed a rapid impairment of liver function reflected by a significant elevation in aspartate aminotransferase, international normalized ratio, bilirubin, and intracranial pressure and a decrease in cerebral perfusion pressure compared with the study group (P<0.05). Mesocaval shunts showed protective effects on grafts with CILW less than 20 and may have a clinical role in the salvage of small-for-size liver grafts. |
| Databáze: |
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