Endothelin-receptor blockade mitigates the adverse effect of preretrieval warm ischemia on posttransplantation renal function in rats1

Autor: Inman, Sharon R., Plott, Wanda K., Pomilee, Ray A., Antonelli, Jodi A., Lewis, Richard M.
Zdroj: Transplantation; May 2003, Vol. 75 Issue: 10 p1655-1659, 5p
Abstrakt: Ischemia-reperfusion injury has been established as a nonimmunologic risk factor for the development of chronic graft nephropathy after renal transplantation. This objective of this study was to determine if oral administration of an endothelin-1 receptor (ET-R) antagonist over a 2-month period after renal transplantation would mitigate long-term dysfunction associated with 30 min of preretrieval warm ischemia (pre-WI).
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