Tumor necrosis factor- in a porcine bronchial model of obliterative bronchiolitis1

Autor: Alho, Hanni S., Maasilta, Paula K., Harjula, Ari L. J., Hämmäinen, Pekka, Salminen, Jukka, Salminen, Ulla-Stina
Zdroj: Transplantation; August 2003, Vol. 76 Issue: 3 p516-523, 8p
Abstrakt: In posttransplant obliterative bronchiolitis (OB), the major pathologic features are inflammation, epithelial cell injury, fibrosis, and obliteration of the small airways. Tumor necrosis factor (TNF)- is a cytokine known to mediate and augment the inflammatory reaction and to enhance fibroblast proliferation. We assessed the role of TNF- in the development of OB in our heterotopic porcine bronchial transplantation model.
Databáze: Supplemental Index