Cyclosporine pharmacokinetics and dose monitoring after lung transplantation comparison between cystic fibrosis and other conditions

Autor: Knoop, Christiane, Vervier, Ingrid, Thiry, Philippe, De Backer, Marc, Kovarik, John M., Rousseau, Annick, Marquet, Pierre, Estenne, Marc
Zdroj: Transplantation; August 2003, Vol. 76 Issue: 4 p683-688, 6p
Abstrakt: In cystic fibrosis (CF), absorption of cyclosporine A (CsA) through the gastrointestinal tract is often impaired because of fat malabsorption. The aim of this study was to compare the steady-state pharmacokinetics of CsA and the inter- and intrasubject variability of CsA exposure in stable lung transplant recipients with and without CF and to determine the best single-time predictors of the area under the curve (AUC).
Databáze: Supplemental Index